Microsatellite instability and survival in rectal cancer
نویسندگان
چکیده
منابع مشابه
Radiotherapy Response in Microsatellite Instability Related Rectal Cancer
Preoperative radiotherapy may improve the resectability and subsequent local control of rectal cancers. However, the extent of radiation induced regression in these tumours varies widely between individuals. To date no reliable predictive marker of radiation sensitivity in rectal cancer has been identified. At the cellular level, radiation injury initiates a complex molecular network of DNA dam...
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Mismatch (MMR) repair system plays a significant role in restoration of stability in the genome. Mutations in mismatch repair genes hamper their activity thus bring about a defect in mismatch repair (MMR) mechanism thereby conferring instability in the microsatellite sequences of both the coding and non-coding regions of the genome. Mutated mismatch repair genes result in the expansion or contr...
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ژورنال
عنوان ژورنال: Cancer Causes & Control
سال: 2009
ISSN: 0957-5243,1573-7225
DOI: 10.1007/s10552-009-9410-3